BHRC BLOG

Understanding GLP-1 Weight Loss Medications: Your Complete 2025 Guide

The landscape of medical weight loss has transformed dramatically with the introduction of GLP-1 receptor agonist medications. These groundbreaking treatments represent a significant advancement in how medical professionals approach weight management, offering hope to individuals who have struggled with traditional diet and exercise approaches alone.

At Beverly Hills Rejuvenation Center, we believe informed patients make better decisions about their health. With locations across California, Nevada, and Arizona including West Hollywood, Los Angeles, Summerlin, and Paradise Valley, we help patients throughout the region understand their options for medically supervised weight loss. This comprehensive guide explores everything you need to know about GLP-1 medications, including the currently available FDA-approved options and the exciting developments on the horizon.

What Are GLP-1 Receptor Agonist Medications?

GLP-1, or glucagon-like peptide-1, is a hormone naturally produced in your intestines after eating. This hormone plays a crucial role in regulating blood sugar levels, slowing stomach emptying, and signaling to your brain that you are full. GLP-1 receptor agonist medications work by mimicking these natural hormones, essentially amplifying their effects to help control appetite and support weight loss.

The development of these medications represents one of the most significant breakthroughs in obesity medicine in decades. Unlike older weight loss drugs that worked primarily on the brain’s reward centers or metabolism, GLP-1 medications target the body’s natural appetite regulation system, leading to more sustainable results with generally favorable safety profiles when used under proper medical supervision.

For patients seeking weight loss support in Los Angeles or weight loss programs in Paradise Valley, understanding how these medications work is the first step toward determining whether they might be appropriate for your individual health goals.

Currently Available FDA-Approved GLP-1 Medications

Two primary categories of GLP-1 medications are currently FDA-approved and available through medically supervised weight loss programs. Understanding the differences between these options helps patients and their healthcare providers make informed treatment decisions.

Semaglutide: The Single Receptor Agonist

Semaglutide was initially developed and approved for treating type 2 diabetes under brand names like Ozempic. Its remarkable weight loss effects led to FDA approval specifically for weight management under the brand name Wegovy. As a GLP-1 receptor agonist, semaglutide works by targeting a single hormone pathway.

Clinical trials have demonstrated that semaglutide can help patients achieve an average weight loss of approximately 15% of their body weight over 68 weeks of treatment. The medication works by reducing appetite and food cravings, slowing gastric emptying to increase feelings of fullness, and helping regulate blood sugar levels. Many patients report that semaglutide helps reduce what some describe as constant food noise in their minds, making it easier to adhere to healthier eating patterns.

Semaglutide is typically administered as a once weekly subcutaneous injection. Treatment begins at a lower dose and is gradually increased over several weeks to help minimize side effects and allow the body to adjust to the medication.

Tirzepatide: The Dual Receptor Agonist

Tirzepatide, available under brand names Mounjaro for diabetes and Zepbound for weight management, represents the next evolution in GLP-1 medications. Unlike semaglutide, tirzepatide targets two hormone receptors simultaneously: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). This dual action approach provides enhanced appetite suppression and metabolic benefits.

Clinical trials have shown tirzepatide to be even more effective than single agonist medications, with patients achieving average weight loss of 20 to 22.5% of their body weight over 72 weeks. The dual receptor mechanism provides more comprehensive metabolic support, potentially leading to greater improvements in body composition.

Like semaglutide, tirzepatide is administered as a once weekly injection with gradual dose titration. The dual agonist approach means tirzepatide may work for some patients who have not achieved their desired results with single agonist medications.

The Future of GLP-1 Medications: Understanding Retatrutide

The field of GLP-1 medications continues to evolve rapidly, with researchers developing new compounds that target additional hormone pathways. Among the most promising medications currently in development is retatrutide, sometimes referred to as the triple G medication. While not yet FDA-approved and not available for prescription, understanding what is coming helps patients stay informed about the evolving landscape of medical weight loss.

What is Retatrutide?

Retatrutide is an investigational medication being developed by Eli Lilly, the same pharmaceutical company that developed tirzepatide. What makes retatrutide unique is its triple agonist mechanism. While semaglutide targets one receptor (GLP-1) and tirzepatide targets two receptors (GLP-1 and GIP), retatrutide targets three: GLP-1, GIP, and glucagon.

The addition of glucagon receptor activation is significant because glucagon plays an important role in metabolism and energy expenditure. By targeting all three pathways simultaneously, retatrutide may provide even more comprehensive metabolic support than currently available medications.

Clinical Trial Results

Phase 2 clinical trials published in the New England Journal of Medicine showed remarkable results. Participants taking retatrutide at the highest dose achieved an average weight loss of 24.2% of their body weight, or approximately 58 pounds, after 48 weeks of treatment. This represents a faster rate of weight loss and greater overall reduction compared to both semaglutide and tirzepatide in their respective trials.

It is important to note that these results are from Phase 2 trials, and Phase 3 trials are currently underway to confirm safety and efficacy in larger patient populations. Eli Lilly has announced they expect to release data from Phase 3 trials in late 2025 or early 2026.

Current Status and Timeline

As of late 2025, retatrutide is not FDA-approved and is not available for prescription use anywhere in the world. The medication is only available through participation in clinical trials. Based on current trial timelines and the FDA approval process, experts estimate potential approval and commercial availability in mid to late 2026 or possibly 2027.

Why Understanding Future Medications Matters

Staying informed about medications in development helps patients have productive conversations with their healthcare providers about current and future treatment options. It also helps set realistic expectations about what the future of medical weight loss may look like. However, it is crucial to focus treatment decisions on what is currently FDA-approved, safe, and available through legitimate medical channels.

How GLP-1 Medications Work in the Body

Understanding the mechanisms behind GLP-1 medications helps explain why they are so effective for weight management. These medications work through multiple pathways simultaneously.

Appetite suppression occurs when GLP-1 medications activate receptors in the brain that regulate hunger and satiety. Patients typically report significantly reduced appetite and fewer food cravings. Many describe a quieting of the constant thoughts about food that previously dominated their daily experience.

Delayed gastric emptying is another key mechanism. By slowing the rate at which food leaves the stomach, these medications help you feel fuller for longer after eating smaller portions. This natural fullness reduces the urge to overeat and makes it easier to consume fewer calories without feeling deprived.

Blood sugar regulation improves because GLP-1 medications enhance insulin secretion when blood sugar rises after meals while also reducing glucagon secretion. This leads to more stable blood sugar levels throughout the day, which can reduce energy crashes and associated cravings for quick energy from sugary or high carbohydrate foods.

Metabolic improvements beyond weight loss have been observed in clinical studies. Patients often experience improvements in cholesterol levels, blood pressure, and markers of inflammation. These benefits contribute to overall cardiovascular health and may reduce the risk of obesity related complications.

Who May Be a Candidate for GLP-1 Medications

GLP-1 medications are not appropriate for everyone, and proper patient selection is essential for safe and effective treatment. Generally, these medications may be appropriate for adults with a body mass index (BMI) of 30 or higher, which is classified as obesity, or adults with a BMI of 27 or higher with at least one weight related health condition such as type 2 diabetes, high blood pressure, or high cholesterol.

Certain individuals should not take GLP-1 medications or require special consideration. These include individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, those with a history of pancreatitis, pregnant or breastfeeding women, individuals with severe gastrointestinal disorders, and those with severe kidney disease.

The best way to determine whether you are a candidate for GLP-1 medications is through a comprehensive consultation with a qualified medical provider who can review your complete health history, current medications, and individual risk factors.

What to Expect from GLP-1 Treatment

When you begin a medically supervised weight loss program with GLP-1 medications, the process typically follows a structured approach designed to maximize results while ensuring safety.

The initial consultation involves a thorough review of your medical history, current medications, and weight loss goals. Lab work is typically ordered to assess your overall health, metabolic function, and eligibility for treatment. A physical examination and body composition analysis establish baseline measurements.

Treatment begins with a low dose that is gradually increased over several weeks. This titration process helps your body adjust to the medication and minimizes potential side effects. Most patients start noticing reduced appetite within the first few weeks of treatment.

Ongoing monitoring through regular appointments allows your healthcare provider to track your progress, adjust medication doses as needed, and address any concerns that arise. These appointments typically include weight and body composition measurements, vital sign monitoring, and discussion of your experience with the medication.

Lifestyle integration is a crucial component of successful treatment. While GLP-1 medications significantly reduce appetite and support weight loss, optimal results come from combining medication with healthy eating habits and appropriate physical activity. Many programs include nutritional counseling and guidance on building sustainable lifestyle habits.

Common Side Effects and How to Manage Them

Like all medications, GLP-1 receptor agonists can cause side effects. Most side effects are gastrointestinal in nature and tend to be most pronounced when starting treatment or increasing doses. Understanding what to expect helps patients manage these effects effectively.

Nausea is the most commonly reported side effect, particularly during the dose titration period. Eating smaller, more frequent meals, avoiding fatty or greasy foods, and staying well hydrated can help minimize nausea. For most patients, nausea diminishes significantly as the body adjusts to the medication.

Other gastrointestinal effects may include diarrhea, constipation, vomiting, and abdominal discomfort. These effects typically occur when treatment begins and improve over time. Dietary modifications and adequate hydration can help manage these symptoms.

Some patients report injection site reactions, though these are generally mild and resolve quickly. Proper injection technique and rotating injection sites helps minimize any local reactions.

More serious side effects are rare but require immediate medical attention. These include symptoms of pancreatitis such as severe abdominal pain, signs of thyroid problems, or severe allergic reactions. Your healthcare provider will educate you on warning signs to watch for and when to seek medical care.

Maximizing Results with GLP-1 Medications

While GLP-1 medications provide powerful support for weight loss, patients who achieve the best long-term results typically combine medication with comprehensive lifestyle modifications. Research consistently shows that the most successful outcomes occur when medication is part of a broader health improvement strategy.

Nutritional optimization during treatment is essential. Though GLP-1 medications reduce appetite, the quality of food consumed still matters significantly. Focusing on lean proteins, vegetables, fruits, whole grains, and healthy fats ensures adequate nutrition while supporting body composition improvements. Many patients find their food preferences naturally shift toward healthier options during treatment.

Physical activity enhances results by preserving lean muscle mass during weight loss and improving overall metabolic health. Even moderate activity like walking, swimming, or light strength training provides significant benefits. As weight decreases, many patients find physical activity becomes easier and more enjoyable.

Behavioral changes developed during treatment help maintain results long-term. Learning to recognize true hunger versus emotional eating, developing mindful eating practices, and establishing consistent meal patterns create habits that persist even after treatment concludes.

Adequate sleep and stress management support weight loss efforts by regulating hormones that influence appetite and metabolism. Prioritizing seven to nine hours of quality sleep and finding effective ways to manage stress improves overall treatment outcomes.

BHRC Medical Weight Loss Locations

Beverly Hills Rejuvenation Center offers comprehensive, medically supervised weight loss programs at convenient locations throughout the western United States. Our experienced medical teams stay current with the latest developments in obesity medicine to ensure patients receive the most effective treatments available.

California: Our West Hollywood and West Los Angeles locations serve the greater Los Angeles area, providing access to comprehensive weight loss programs in one of the nation’s most health-conscious communities. The lifestyle-oriented culture of Southern California supports the healthy habits that complement medical treatment.

Nevada: Our Summerlin location in Las Vegas offers residents of the Las Vegas Valley access to advanced medical weight loss treatments. The desert climate and active outdoor lifestyle create excellent conditions for incorporating physical activity into your weight loss journey.

Arizona: Our Paradise Valley location serves the Phoenix metropolitan area, bringing world-class weight loss treatments to Arizona residents. The year-round warm weather supports outdoor activities that enhance treatment results.

Each BHRC location offers the same commitment to excellence, personalized care, and medically supervised treatment protocols that have made us a leader in longevity and wellness medicine.

Choosing the Right Provider for GLP-1 Treatment

Selecting a qualified provider for GLP-1 medication treatment is one of the most important decisions in your weight loss journey. Key factors to consider include the provider’s qualifications and experience with medical weight loss, the comprehensiveness of the program, the quality of ongoing support and monitoring, and the facility’s reputation and patient reviews.

Look for providers who offer thorough initial evaluations including appropriate lab work and medical history review. Programs should include regular follow-up appointments with medication adjustments as needed and access to medical staff between appointments if questions or concerns arise.

Be cautious of providers who offer GLP-1 medications without proper medical evaluation or ongoing monitoring. These medications require appropriate patient selection and medical supervision for safe and effective use.

Frequently Asked Questions About GLP-1 Medications

How much weight can I expect to lose with GLP-1 medications?

Individual results vary based on factors including starting weight, medication type, dosage, and adherence to lifestyle modifications. Clinical trials show average weight loss of approximately 15% with semaglutide and 20 to 22% with tirzepatide over the course of treatment. Some patients lose more and some less. Your healthcare provider can help set realistic expectations based on your individual situation and goals.

How long do I need to take GLP-1 medications?

The duration of treatment varies by individual. Many patients benefit from longer-term treatment as studies show weight regain is common after stopping medication. Your healthcare provider will work with you to develop a treatment plan that aligns with your goals. Some patients transition to lower maintenance doses after achieving initial weight loss, while others may eventually discontinue with careful monitoring and strong lifestyle habits in place.

Are GLP-1 medications covered by insurance?

Insurance coverage for GLP-1 medications varies significantly by plan and carrier. Some insurance plans cover these medications for diabetes treatment but not for weight loss, while others provide coverage for weight management under specific criteria. Many patients utilize HSA or FSA funds for treatment. Your provider’s staff can often help determine coverage options and provide documentation to support insurance claims.

What is the difference between semaglutide and tirzepatide?

Both medications are GLP-1 receptor agonists administered as weekly injections, but they differ in their mechanisms. Semaglutide targets only the GLP-1 receptor, while tirzepatide targets both GLP-1 and GIP receptors. This dual action generally results in greater weight loss with tirzepatide compared to semaglutide. Your healthcare provider can help determine which medication may be most appropriate based on your individual needs, medical history, and treatment goals.

When will retatrutide be available?

Retatrutide is currently in Phase 3 clinical trials and is not FDA-approved. Based on current trial timelines and the typical FDA review process, experts estimate potential approval and commercial availability could occur in mid to late 2026 or possibly 2027. However, drug approval timelines can be affected by many factors and are not guaranteed. Until FDA approval, retatrutide is only available through participation in official clinical trials.

Can I take GLP-1 medications if I have diabetes?

GLP-1 medications were originally developed for type 2 diabetes management and are FDA-approved for this use. Many patients with diabetes benefit from these medications for both blood sugar control and weight loss. However, if you have diabetes and are already on diabetes medications, careful coordination with your healthcare providers is essential to avoid complications like hypoglycemia. A comprehensive evaluation is necessary to determine the safest approach for your situation.

What happens if I miss a dose?

If you miss a weekly dose, the general guidance is to take it as soon as you remember if it has been five days or less since your scheduled dose. If more than five days have passed, skip the missed dose and take your next dose on the regularly scheduled day. Do not take extra medication to make up for missed doses. Your healthcare provider will give you specific instructions based on your medication and situation.

How do I get started with GLP-1 treatment at BHRC?

Getting started begins with scheduling a consultation at your nearest Beverly Hills Rejuvenation Center location. During your consultation, you will discuss your health history, weight loss goals, and determine whether GLP-1 medications may be appropriate for you. If you are a candidate, lab work will be ordered, and once results are reviewed, treatment can typically begin within one to two weeks. We have locations in West Hollywood, Los Angeles, Summerlin, Paradise Valley, and many other cities to serve you.

Take the Next Step in Your Weight Loss Journey

The availability of GLP-1 medications has created unprecedented opportunities for individuals struggling with weight management. Whether you are considering semaglutide, tirzepatide, or simply want to learn more about your options, the first step is consulting with a qualified medical provider who can evaluate your individual situation and recommend an appropriate treatment plan.

At Beverly Hills Rejuvenation Center, our medical teams are experienced in helping patients achieve their weight loss goals through comprehensive, medically supervised programs. We stay current with the latest developments in obesity medicine to ensure our patients have access to the most effective treatments available.

Contact your nearest BHRC location today to schedule your consultation:

• → West Hollywood, California
• → West Los Angeles, California
• → Summerlin, Las Vegas, Nevada
• → Paradise Valley, Arizona
• → View All BHRC Locations

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