Extended IGF-1
Long-acting IGF-1 for muscle growth and recovery.
IGF-1 LR3 is a long-acting variant of insulin-like growth factor with enhanced stability and bioavailability. Engineered with a 13-amino acid extension, it delivers sustained anabolic signaling for muscle growth, recovery, and metabolic optimization beyond what natural IGF-1 can achieve.
20-30hr
Half-Life
83
Amino Acids
3X
More Potent
22+
BHRC Locations
Available Option
A synthetic analog of insulin-like growth factor engineered for extended half-life and enhanced anabolic activity through direct IGF-1 receptor activation.
IGF-1 LR3 1mg per vial
Ideal For
Athletes and patients seeking accelerated muscle growth, enhanced recovery, improved body composition, and sustained anabolic signaling with fewer administrations.
The Science
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a synthetic analog of human IGF-1, modified with a 13-amino acid N-terminal extension that dramatically extends its half-life from minutes to 20-30 hours. This structural modification also reduces its binding affinity to IGF binding proteins, allowing it to remain bioactive in circulation significantly longer than endogenous IGF-1.
By binding directly to IGF-1 receptors on muscle cells, IGF-1 LR3 activates downstream anabolic pathways including PI3K/Akt and MAPK signaling—promoting protein synthesis, glucose uptake, cellular proliferation, and satellite cell activation. This makes it exceptionally effective for muscle growth, recovery from injury, and metabolic optimization.
Unlike growth hormone which works upstream through the GH/IGF-1 axis, IGF-1 LR3 provides direct receptor activation with sustained exposure—offering a targeted approach to anabolic enhancement. At BHRC, we leverage this peptide for patients seeking optimized body composition, athletic performance, and recovery acceleration.
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How It Works
IGF-1 LR3 binds directly to IGF-1 receptors on muscle and other tissues, triggering powerful anabolic cascades that promote protein synthesis, cellular growth, and metabolic enhancement with sustained activity.
Binds to IGF-1 receptors on muscle cells with high affinity, initiating tyrosine kinase signaling that activates critical anabolic pathways for growth and recovery.
Activates the PI3K/Akt pathway which increases protein synthesis, glucose uptake, and cellular survival while inhibiting muscle protein breakdown.
Stimulates muscle satellite cells to proliferate and differentiate, supporting muscle repair, hypertrophy, and the creation of new muscle fibers for enhanced growth capacity.
Clinical Benefits
Direct IGF-1 receptor activation promotes rapid muscle protein synthesis and satellite cell proliferation, supporting significant hypertrophy and strength gains beyond natural capacity.
Stimulates cellular repair mechanisms and reduces recovery time between training sessions, allowing for higher training frequency and faster return from injury.
Promotes lean muscle mass while supporting fat oxidation through enhanced metabolic activity, improving muscle-to-fat ratio and overall physique aesthetics.
Increases glucose uptake in muscle tissue and enhances insulin sensitivity, supporting improved nutrient partitioning and metabolic health markers.
The 20-30 hour half-life means sustained anabolic signaling with fewer administrations compared to regular IGF-1, providing convenience and consistent results.
Lower affinity for IGF binding proteins means more free, bioactive IGF-1 LR3 in circulation—maximizing receptor engagement and anabolic effects.
Your Journey
Our medical team guides you through every step—from initial consultation to ongoing optimization.
Meet with our physician to assess your goals, health status, and determine if IGF-1 LR3 therapy is appropriate for your needs.
Comprehensive testing including IGF-1, glucose, insulin, metabolic panel, and hormone levels to establish baseline health markers.
Personalized treatment plan with precise dosing, injection training, cycle duration, and lifestyle recommendations to maximize muscle growth and recovery.
Regular follow-ups with progress tracking, lab monitoring, and protocol adjustments to ensure safe, effective anabolic results.
Safety & Candidacy
IGF-1 LR3 is a well-researched peptide analog with documented anabolic effects in preclinical and research settings. While not FDA-approved for performance enhancement, it’s used in supervised medical protocols for body composition optimization and recovery support.
4-6wks
Typical cycle duration with proper medical monitoring and planned rest periods
1x/day
Once-daily subcutaneous injection due to extended half-life
Questions
IGF-1 LR3 features a 13-amino acid N-terminal extension that extends its half-life from minutes to 20-30 hours and reduces binding to IGF binding proteins. This means it stays bioactive in your system much longer, provides more sustained anabolic signaling, and requires less frequent administration compared to regular IGF-1.
IGF-1 LR3 is administered via subcutaneous injection, typically once daily due to its extended half-life. Our clinical team provides comprehensive training on proper reconstitution, injection technique, site rotation, and storage. Some protocols may use post-workout timing to maximize nutrient partitioning to muscle tissue.
Users typically report accelerated muscle growth, enhanced recovery between training sessions, improved muscle fullness and vascularity, better nutrient partitioning, and noticeable body composition changes within 2-4 weeks. Results are maximized when combined with proper training, nutrition, and adequate protein intake. Individual responses vary based on training status, diet, and genetics.
Typical cycles range from 4-6 weeks under medical supervision, followed by an off period to maintain receptor sensitivity. Longer continuous use may lead to receptor downregulation and diminished returns. Your physician will design a protocol based on your goals, response, and monitoring data including glucose metabolism and IGF-1 levels.
Potential side effects include hypoglycemia (low blood sugar), joint discomfort, water retention, and jaw/facial changes with prolonged use. Some users experience increased appetite or insulin sensitivity changes. Blood glucose monitoring is important, especially for those with diabetes or insulin resistance. All use should be under physician supervision with regular lab monitoring.
Ideal candidates are adults seeking accelerated muscle growth, enhanced recovery, or body composition optimization who have plateaued with conventional training and nutrition. Contraindications include active malignancy, uncontrolled diabetes, pregnancy, or history of certain cancers. A physician consultation with comprehensive lab work is required to assess candidacy.
Monitoring includes regular glucose testing, IGF-1 levels, metabolic panels, insulin sensitivity markers, and clinical assessments. Body composition tracking via DEXA or other methods quantifies muscle gain and fat loss. Your physician schedules follow-ups every 2-4 weeks during active cycles to ensure safety and optimize results.
Get Started
Schedule a consultation with our medical team to learn if IGF-1 LR3 peptide therapy is right for your muscle growth and performance goals.
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Or call us directly: +1 213-325-3373
*These statements have not been evaluated by the Food and Drug Administration. IGF-1 LR3 is not FDA-approved for performance enhancement or body composition optimization. Use is off-label and administered under medical supervision for research and therapeutic purposes. Results vary by individual based on genetics, training, nutrition, and adherence. IGF-1 LR3 may affect glucose metabolism and insulin sensitivity. Contraindicated in patients with active malignancy, uncontrolled diabetes, or certain medical conditions. A consultation with our medical team and comprehensive laboratory testing are required to determine if this therapy is appropriate for you. This product is intended for use only under qualified medical supervision.
