Oral Anti-Inflammatory Peptide
Targeted Gut Health & Inflammatory Support
KPV is a naturally occurring tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH) that provides potent anti-inflammatory effects. Delivered in oral capsule form, KPV works directly in the GI tract to support gut health, reduce intestinal inflammation, and promote immune balance—ideal for those managing inflammatory bowel conditions, leaky gut, or chronic digestive issues.
250mcg
Per Capsule
Oral
Administration
1x
Daily Dosing
GI
Direct Action
Available Dosing
Medical-grade oral peptide therapy formulated for optimal bioavailability and GI tract targeting.
Standard therapeutic dose
Ideal For
Individuals seeking gut health support, managing IBD, IBS, or intestinal permeability, or looking for oral anti-inflammatory support without injections.
The Science
KPV is a tripeptide consisting of three amino acids: lysine-proline-valine. It is a C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH), a naturally occurring peptide in the body that plays a crucial role in immune regulation and anti-inflammatory signaling.
Unlike many peptides that require injection, KPV is uniquely suited for oral administration. When taken orally, KPV remains stable through the digestive tract and exerts its therapeutic effects directly at the site of GI inflammation—making it particularly valuable for intestinal health.
Research demonstrates KPV’s ability to inhibit inflammatory pathways, support intestinal barrier function, promote wound healing in the gut lining, and modulate immune responses without suppressing overall immune function. This makes it a targeted, well-tolerated option for chronic inflammatory conditions affecting the digestive system.
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How It Works
KPV targets multiple inflammatory pathways to support gut health and immune balance.
As a derivative of α-MSH, KPV activates melanocortin receptors, triggering anti-inflammatory signaling cascades that reduce cytokine production and calm immune overactivity.
KPV directly inhibits nuclear factor kappa B (NF-κB), a key regulator of inflammatory gene expression, reducing the production of pro-inflammatory mediators in intestinal tissues.
Rather than broadly suppressing immunity, KPV selectively modulates inflammatory responses, supporting healthy immune tolerance in the gut while preserving protective immune function.
Clinical Benefits
Reduces intestinal inflammation and helps manage symptoms associated with IBD, IBS, Crohn’s disease, and ulcerative colitis through direct anti-inflammatory action.
Supports tight junction integrity and helps restore proper intestinal permeability, addressing leaky gut syndrome and improving nutrient absorption.
Promotes healing and regeneration of damaged intestinal tissue, supporting recovery from inflammation-related mucosal damage in the GI tract.
Modulates immune responses without suppression, helping establish oral tolerance and reducing inappropriate immune reactions to food and commensal bacteria.
Reduces bloating, discomfort, and digestive distress associated with chronic inflammatory conditions, improving overall quality of life and daily function.
While targeting the gut, KPV may also provide broader anti-inflammatory benefits throughout the body, potentially supporting joint health, skin conditions, and overall inflammation.
Your Journey
Our medical team guides you through every step—from initial consultation to ongoing optimization.
Comprehensive evaluation of your digestive health, symptoms, and treatment goals with our specialized physicians.
Custom KPV dosing plan designed for your specific condition, with consideration for timing and complementary therapies.
Pharmaceutical-grade KPV capsules shipped directly to your door with clear administration instructions.
Regular follow-up assessments to track symptom improvement, adjust dosing as needed, and optimize your outcomes.
Safety & Candidacy
KPV oral therapy is remarkably well-tolerated due to its natural origin and targeted mechanism. As a derivative of α-MSH, it works with the body’s existing regulatory systems rather than against them.
1x
Daily capsule administration—simple, convenient, and injection-free for consistent GI support
Natural
Derived from α-MSH, a peptide naturally found in the body that regulates inflammation and immune function
Questions
KPV is primarily used for inflammatory bowel conditions including Crohn’s disease, ulcerative colitis, IBS, and intestinal permeability (leaky gut). It may also support other inflammatory conditions affecting the gut lining, food sensitivities, and overall digestive health. Research suggests benefits for wound healing, immune modulation, and systemic inflammation as well.
KPV is uniquely suited for oral administration because it remains stable through the digestive tract and exerts its therapeutic effects directly in the GI system. This makes it ideal for gut-specific conditions. While many peptides require injection to avoid degradation, KPV’s mechanism actually benefits from oral delivery, targeting inflammation at the source in the intestinal lining.
KPV is typically taken once daily on an empty stomach—ideally first thing in the morning or between meals. This ensures maximum contact with the intestinal lining and optimal therapeutic effect. Your physician will provide specific timing recommendations based on your condition and treatment goals.
Response times vary by individual and condition severity. Some patients notice improvements in digestive comfort within 1-2 weeks, while more significant changes in inflammation markers and gut healing may take 4-8 weeks of consistent use. Our medical team monitors your progress and adjusts dosing as needed to optimize outcomes.
KPV is generally very well-tolerated with minimal side effects. Because it’s a naturally occurring peptide fragment, adverse reactions are rare. Some patients may experience mild digestive changes during the first few days as their body adjusts. Unlike immunosuppressive medications, KPV does not increase infection risk or cause systemic side effects.
KPV can often be used alongside other therapies, including conventional medications for IBD, probiotics, and nutritional supplements. However, it’s essential to discuss all current medications and supplements with your BHRC physician during your consultation to ensure safe and effective integration into your treatment plan.
Yes, KPV peptide therapy requires a prescription from a licensed physician. At BHRC, we conduct a comprehensive medical evaluation to determine if KPV is appropriate for your specific condition and health status. This ensures safe, effective treatment tailored to your individual needs.
Get Started
Schedule a consultation with our medical team to learn if KPV peptide therapy is right for your wellness journey.
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Or call us directly: +1 213-325-3373
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. KPV peptide therapy is a compounded medication available by prescription only. Not all patients will respond to therapy, and individual results may vary. KPV should be used under medical supervision as part of a comprehensive treatment plan for inflammatory GI conditions. A consultation with our medical team and baseline evaluation are required to determine if this therapy is appropriate for you.
