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Peptide Therapy

KPV Peptide: Benefits, Dosing & Safety

KPV (Lysine-Proline-Valine) is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH), studied for its anti-inflammatory effects — particularly in the gastrointestinal tract. It works by acting on the PepT1 transporter found on intestinal and immune cells, where research shows it inhibits inflammatory signaling pathways (NF-kB and MAP kinase) and reduces pro-inflammatory cytokine secretion.

Typical BHRC Protocol
Category: Inflammation support
Concentration: 10mg/10mL (1mg/mL)
Typical dose: 500mcg (50 units)
Frequency: Monday–Friday
Cycle: 12 weeks on, 4 weeks off
Starting price: $112 per vial

Frequently Asked Questions

What is KPV peptide?
KPV (Lysine-Proline-Valine) is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied for its anti-inflammatory effects, particularly in the gastrointestinal tract, where it acts via the PepT1 transporter expressed on intestinal and immune cells.
What is KPV used for?
KPV is most studied for gut inflammation and conditions involving inflammatory bowel activity. Research shows it inhibits NF-kB and MAP kinase inflammatory signaling pathways and reduces pro-inflammatory cytokine secretion, with oral and injectable forms both studied in research settings.
How is KPV dosed?
At BHRC, KPV is typically dosed at 500mcg (50 units on an insulin syringe from a 10mg/10mL, 1mg/mL vial), administered Monday through Friday, in cycles of 12 weeks on followed by 4 weeks off. Your provider will determine the right protocol for your goals during a consultation.
Is KPV safe?
KPV is generally well-tolerated in the research studied to date, with a favorable safety profile compared to broader-acting anti-inflammatory agents. As with any peptide therapy, KPV should only be used under physician supervision, and it is not a substitute for treatment of diagnosed medical conditions like IBD without your physician’s involvement.
How much does KPV cost at BHRC?
KPV pricing at BHRC starts at $112 per vial. Exact pricing depends on your specific protocol and any combination with other peptides. Book a free consultation for a personalized quote.
Clinical Reference

Dalmasso G, et al. “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” Gastroenterology. PubMed: 18061177

Medically reviewed by the BHRC Medical Team. This page is for educational purposes and does not constitute medical advice. Meet our providers.

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