BHRC BLOG
Hyperdilute Radiesse: What It Is, What the FDA Approved, and What It Costs
Injectables · Radiesse
Hyperdilute Radiesse is the same Radiesse, mixed with more saline so it spreads thinly and improves skin quality. In 2026 the FDA approved one diluted use. Here is what it is, what is on-label, and what it costs.
What is hyperdilute Radiesse?
Hyperdilute (or hyperdiluted) Radiesse is ordinary Radiesse mixed with extra sterile saline before it is injected. Merz describes it as a preparation “mixed with a higher volume of sterile saline” so it can be spread thinly across a larger area. Standard, full-strength Radiesse is used for lift and volume in the face or hands. Diluted, it adds little or no volume and works mainly by prompting your skin to make new collagen and elastin, so it is used for crepey, thin or lined skin rather than to fill a fold.
Is hyperdilute Radiesse FDA approved?
Partly, and this changed in 2026. Many pages online still say it is not approved. On March 31, 2026 the FDA approved Radiesse “diluted 1:2 with 0.9% sterile saline solution” for the correction of décolleté (chest) wrinkles in adults 22 and older. Merz announced it on April 8, 2026. That is the only diluted use on the label.
| Use | Status |
|---|---|
| Chest (décolleté) wrinkles, diluted 1:2 with saline, age 22+ | FDA approved, March 2026 |
| Facial wrinkles and folds, full strength | FDA approved, 2006 |
| Backs of the hands | FDA approved, 2015 |
| Jawline contour, Radiesse (+) | FDA approved, 2021 |
| Diluted on the face for skin quality, neck, upper arms, abdomen, thighs, knees, buttocks | Off-label |
Off-label uses of diluted calcium hydroxylapatite are described in expert consensus papers, including one covering the face, neck, chest, buttocks, thighs, arms, abdomen, knees and elbows, which also says more clinical studies are needed. Off-label means the FDA has not reviewed that use. Note that the FDA’s filler guidance recommends against injecting fillers into the neck and against using fillers to increase buttock size.
What the FDA chest study showed
The approval rests on a study of 152 adults at 9 sites, sponsored by Merz. People in the treatment group had three sessions, at day 1, week 6 and week 12, with an optional retreatment at week 36. Each session used up to 4.5 mL of mixture: one 1.5 mL syringe of Radiesse plus 3 mL of saline, injected with a cannula.
- At 24 weeks, 71.2% of treated people improved by at least one point on a chest wrinkle scale, judged by a blinded evaluator, compared with 6.3% of untreated people.
- The responder rate stayed above 60% at 60 weeks, and people were followed to 84 weeks.
- Diluted Radiesse was not seen on mammograms or breast ultrasound in 75 patients. Injections are not made over or including breast tissue.
How much does hyperdilute Radiesse cost?
Hyperdilute Radiesse uses the same syringes as regular Radiesse, so the product cost is per syringe. What changes the total is how many syringes and sessions your plan uses. In the FDA chest study that was one syringe per session over three sessions, but your provider plans the amount for your skin and the area.
| Clinic | Radiesse, per syringe |
|---|---|
| West Hollywood | $900 |
| West Los Angeles | $900 |
| Westlake Village | $800 |
| Valencia | $800 |
| Downtown Summerlin | $900 |
| Henderson | $700 ($560 Beauty Bank member) |
| Paradise Valley | $900 |
| Houston CityCentre | $800 |
| Houston River Oaks | $800 |
List prices from each clinic’s current price sheet, November 2026. New clients save 15% on a first single syringe at West Hollywood, West LA, Westlake Village, Valencia, Downtown Summerlin and Paradise Valley.
As a simple example using the study’s schedule, three sessions of one syringe at $800 a syringe would be $2,400 in product. That is arithmetic, not a quote; your clinic confirms your plan and price at consultation.
What a hyperdilute Radiesse appointment involves
- Consultation. Your provider looks at skin quality and laxity and tells you whether the area is on-label (the chest) or off-label.
- Mixing. The syringe is mixed with sterile saline in a set ratio just before treatment.
- Injection. The mixture is fanned out under the skin, usually with a blunt cannula through a few entry points.
- After. Expect some swelling, redness and bruising, mostly settling within a week. Keep the area out of strong sun and heat for about a day. Change builds over the following months.
Who should not have it
The same contraindications apply as for any Radiesse: severe allergies or a history of anaphylaxis, an allergy to its ingredients, and bleeding disorders. It is deferred if there is an active skin infection or inflammation in the area. For the chest, safety has not been established in pregnancy, breastfeeding or under age 22. If you are prone to keloid scars, tell your provider; that has not been studied.
For full-strength Radiesse, what it treats and how it compares with Sculptra, see our Radiesse guide and prices. For whether it can be dissolved, read is Radiesse reversible.
Hyperdilute Radiesse near you
All nine BHRC clinics offer Radiesse. Ask your clinic whether it offers diluted Radiesse and who on the team has completed Merz’s chest training. Choose your clinic:
Frequently asked questions
What is the dilution for hyperdilute Radiesse?
The FDA-approved chest use is a 1:2 dilution with 0.9% sterile saline, one 1.5 mL syringe of Radiesse mixed with 3 mL of saline. Other ratios used off-label are set by the injector.
Is hyperdilute Radiesse FDA approved?
Yes for chest (décolleté) wrinkles in adults 22 and over, since March 31, 2026. Other diluted uses, such as the neck, arms, abdomen, face skin quality or buttocks, are off-label.
How many sessions of hyperdilute Radiesse will I need?
In the FDA chest study people had three sessions, about six weeks apart. Your provider sets the plan for your skin and the area.
How much does hyperdilute Radiesse cost?
At BHRC, Radiesse is $700 to $900 a syringe depending on the clinic, and your total depends on how many syringes and sessions your plan uses. Your clinic confirms the price at consultation.
How long does hyperdilute Radiesse last?
In the chest study more than 60% of treated people were still responders at 60 weeks. Merz reports Radiesse results in general lasting up to two years.
Can hyperdilute Radiesse be used on the buttocks?
Only off-label, and the FDA recommends against using fillers to increase buttock size. See our page on the Radiesse butt lift for what that means.
Can hyperdilute Radiesse be dissolved?
No. Diluted or not, Radiesse is not hyaluronic acid, and no reversal agent is approved.
References
- U.S. Food and Drug Administration. Summary of Safety and Effectiveness Data, PMA P050052/S162 (approved March 31, 2026): diluted RADIESSE for décolleté wrinkles. accessdata.fda.gov
- Merz Aesthetics press release (April 8, 2026). FDA approval of RADIESSE for wrinkles in the décolleté area. businesswire.com
- Merz Aesthetics. RADIESSE injectable implant instructions for use (face and décolleté, 2026): composition, indications, warnings, precautions, clinical studies. radiesse.com
- Merz Aesthetics. RADIESSE frequently asked questions: results, duration, hyperdiluted RADIESSE. radiesse.com
- de Almeida AT, et al. Consensus recommendations for the use of hyperdiluted calcium hydroxyapatite (Radiesse) as a face and body biostimulatory agent. Plast Reconstr Surg Glob Open. 2019. PMID 31044123. pmc.ncbi.nlm.nih.gov
- U.S. Food and Drug Administration. Dermal fillers (soft tissue fillers): risks, removal and unapproved uses. fda.gov
Beverly Hills Rejuvenation Center. This content is general education and does not create a provider-patient relationship or constitute medical advice. Candidacy, dosing, results and pricing vary by person and by clinic and are confirmed at your consultation. Prices shown are standard list prices as of November 2026 and exclude promotions. Written and reviewed by the BHRC clinical team.
